Structure of PDB 8w0z Chain A

Receptor sequence
>8w0zA (length=395) Species: 9606 (Homo sapiens) [Search protein sequence]
ERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAG
EVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAYSNCSGPG
FSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQG
IKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLF
LVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYY
IMKELPQQRLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHK
LAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDC
VQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVF
3D structure
PDB8w0z Structural basis for expanded substrate specificities of human long chain acyl-CoA dehydrogenase and related acyl-CoA dehydrogenases.
ChainA
Resolution2.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A I170 M172 T173 G178 S179 F203 I204 S205 V407 Y411 T414 E416 I137 M139 T140 G145 S146 F170 I171 S172 V374 Y378 T381 E383
BS02 FAD A R317 F320 L327 Q385 L386 G389 R284 F287 L294 Q352 L353 G356
Gene Ontology
Molecular Function
GO:0000062 fatty-acyl-CoA binding
GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity
GO:0005515 protein binding
GO:0016401 palmitoyl-CoA oxidase activity
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0001659 temperature homeostasis
GO:0006631 fatty acid metabolic process
GO:0019254 carnitine metabolic process, CoA-linked
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042413 carnitine catabolic process
GO:0042758 long-chain fatty acid catabolic process
GO:0044242 cellular lipid catabolic process
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0046322 negative regulation of fatty acid oxidation
GO:0090181 regulation of cholesterol metabolic process
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0031966 mitochondrial membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8w0z, PDBe:8w0z, PDBj:8w0z
PDBsum8w0z
PubMed38839792
UniProtP28330|ACADL_HUMAN Long-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADL)

[Back to BioLiP]