Structure of PDB 8w0s Chain A

Receptor sequence

>8w0sA (length=213) Species: 9606 (Homo sapiens)

PLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVV
PLGTWRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAK
GDSRYILGDNFTVCMETITACLWGPLSLWVVIAFLRQHPLRFILQLVVSV
GQIYGDVLYFLTEHRDGFQHGELGHPLYFWFYFVFMNALWLVLPGVLVLD
AVKHLTHAQSTLD

3D structure

• PDB: 8w0s Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.
• Chain: A
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1AEV	A	L35 T39 E80 W101 Y104 N193 W196	L29 T33 E74 W95 Y98 N187 W190

Gene Ontology

Molecular Function

• GO:0000247 C-8 sterol isomerase activity
• GO:0004769 steroid delta-isomerase activity
• GO:0005515 protein binding
• GO:0016853 isomerase activity
• GO:0042802 identical protein binding
• GO:0047750 cholestenol delta-isomerase activity

Biological Process

• GO:0006695 cholesterol biosynthetic process
• GO:0008203 cholesterol metabolic process
• GO:0016126 sterol biosynthetic process
• GO:0030097 hemopoiesis
• GO:0033489 cholesterol biosynthetic process via desmosterol
• GO:0033490 cholesterol biosynthetic process via lathosterol
• GO:0043931 ossification involved in bone maturation

Cellular Component

• GO:0005634 nucleus
• GO:0005635 nuclear envelope
• GO:0005783 endoplasmic reticulum
• GO:0005789 endoplasmic reticulum membrane
• GO:0016020 membrane
• GO:0031410 cytoplasmic vesicle
• GO:0031965 nuclear membrane

External links

• PDB: RCSB:8w0s, PDBe:8w0s, PDBj:8w0s
• PDBsum: 8w0s
• PubMed: 38470227
• UniProt: Q15125|EBP_HUMAN 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Gene Name=EBP)