Structure of PDB 8w0r Chain A

Receptor sequence
>8w0rA (length=213) Species: 9606 (Homo sapiens) [Search protein sequence]
PLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVV
PLGTWRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAK
GDSRYILGDNFTVCMETITACLWGPLSLWVVIAFLRQHPLRFILQLVVSV
GQIYGDVLYFLTEHRDGFQHGELGHPLYFWFYFVFMNALWLVLPGVLVLD
AVKHLTHAQSTLD
3D structure
PDB8w0r Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.
ChainA
Resolution2.8 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AEU A L32 F36 I75 E80 W101 Y104 D162 M192 W196 L26 F30 I69 E74 W95 Y98 D156 M186 W190
Gene Ontology
Molecular Function
GO:0000247 C-8 sterol isomerase activity
GO:0004769 steroid delta-isomerase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0042802 identical protein binding
GO:0047750 cholestenol delta-isomerase activity
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0016126 sterol biosynthetic process
GO:0030097 hemopoiesis
GO:0033489 cholesterol biosynthetic process via desmosterol
GO:0033490 cholesterol biosynthetic process via lathosterol
GO:0043931 ossification involved in bone maturation
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0031965 nuclear membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w0r, PDBe:8w0r, PDBj:8w0r
PDBsum8w0r
PubMed38470227
UniProtQ15125|EBP_HUMAN 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Gene Name=EBP)

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