Structure of PDB 8vzq Chain A

Receptor sequence
>8vzqA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLA
QLLLILSHIRHMSNKGMEHLYNVVPSYDLLLEMLDA
3D structure
PDB8vzq Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AHX A M343 L346 T347 E353 L387 M388 F404 M421 G521 L525 V534 M38 L41 T42 E48 L82 M83 F99 M116 G216 L220 V224
External links
PDB RCSB:8vzq, PDBe:8vzq, PDBj:8vzq
PDBsum8vzq
PubMed38830107
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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