Structure of PDB 8vzo Chain A

Receptor sequence
>8vzoA (length=416) Species: 10090 (Mus musculus) [Search protein sequence]
SVIKVSKRRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDW
LSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAWVKLGSLEPH
LFPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLG
IAIGFLVPPVLVPNIKDPEKLAYHISIMFYIIGGVATFLFILVIIVFKEK
PKHPPSRAQSLSYASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLL
NRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVV
YIMTLVGMVVYTFTLNLNHLWVVFITAGTLGFFMTGYLPLGFEFAVELTY
PESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGS
ALTAFIKSDLRRQRAN
3D structure
PDB8vzo Structural and molecular basis of choline uptake into the brain by FLVCR2
ChainA
Resolution2.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CHT A N121 A122 W125 Q214 L218 N245 N23 A24 W27 Q116 L120 N147
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015220 choline transmembrane transporter activity
GO:0015232 heme transmembrane transporter activity
GO:0020037 heme binding
GO:0022857 transmembrane transporter activity
GO:0034228 ethanolamine transmembrane transporter activity
Biological Process
GO:0001701 in utero embryonic development
GO:0002040 sprouting angiogenesis
GO:0007420 brain development
GO:0010467 gene expression
GO:0015871 choline transport
GO:0015886 heme transport
GO:0034229 ethanolamine transport
GO:0055085 transmembrane transport
GO:0097102 endothelial tip cell fate specification
GO:0150104 transport across blood-brain barrier
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0031966 mitochondrial membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8vzo, PDBe:8vzo, PDBj:8vzo
PDBsum8vzo
PubMed38693257
UniProtQ91X85|FLVC2_MOUSE Heme transporter FLVCR2 (Gene Name=Flvcr2)

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