Structure of PDB 8vx0 Chain A

Receptor sequence

>8vx0A (length=464) Species: 9606 (Homo sapiens) [Search protein sequence]

KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL
HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRHFS
LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV
ICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFP
GTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHN
QPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEI
ERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR
NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMP
FSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFA
SVPPFYQLCFIPIH

3D structure

PDB

8vx0 Structural and biophysical analysis of cytochrome P450 2C9*14 and *27 variants in complex with losartan

Chain

Resolution

3.05 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.14.1: unspecific monooxygenase.
1.14.14.51: (S)-limonene 6-monooxygenase.
1.14.14.52: (S)-limonene 7-monooxygenase.
1.14.14.53: (R)-limonene 6-monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	LSN	A	R108 L201 N204 V237 V292 G296 A297 L362	R81 L174 N177 V210 V265 G269 A270 L335
BS02	LSN	A	F226 P227 G228 T229 K232	F199 P200 G201 T202 K205
BS03	HEM	A	R97 V113 R124 A297 G298 T301 S365 L366 H368 P427 F428 S429 R433 C435 G437	R70 V86 R97 A270 G271 T274 S338 L339 H341 P400 F401 S402 R406 C408 G410

Gene Ontology

	Molecular Function
GO:0004497	monooxygenase activity
GO:0008392	arachidonate epoxygenase activity
GO:0008395	steroid hydroxylase activity
GO:0008404	arachidonate 14,15-epoxygenase activity
GO:0008405	arachidonate 11,12-epoxygenase activity
GO:0016491	oxidoreductase activity
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0018675	(S)-limonene 6-monooxygenase activity
GO:0018676	(S)-limonene 7-monooxygenase activity
GO:0020037	heme binding
GO:0034875	caffeine oxidase activity
GO:0046872	metal ion binding
GO:0052741	(R)-limonene 6-monooxygenase activity
GO:0070330	aromatase activity

	Biological Process
GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0008210	estrogen metabolic process
GO:0016098	monoterpenoid metabolic process
GO:0019369	arachidonate metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0019627	urea metabolic process
GO:0032787	monocarboxylic acid metabolic process
GO:0042178	xenobiotic catabolic process
GO:0042759	long-chain fatty acid biosynthetic process
GO:0043603	amide metabolic process
GO:0046456	icosanoid biosynthetic process
GO:0070989	oxidative demethylation
GO:0097267	omega-hydroxylase P450 pathway

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8vx0, PDBe:8vx0, PDBj:8vx0
PDBsum	8vx0
PubMed	38852293
UniProt	P11712\|CP2C9_HUMAN Cytochrome P450 2C9 (Gene Name=CYP2C9)

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