Structure of PDB 8vw5 Chain A

Receptor sequence
>8vw5A (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
QAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRL
ILSRYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEENS
QDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFG
DKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFT
RLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRL
SCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSY
NPDL
3D structure
PDB8vw5 Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.
ChainA
Resolution1.76 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D80 Q83 D43 Q46
BS02 CA A D221 T223 N225 Y227 E232 D184 T186 N188 Y190 E195
BS03 A1AD4 A Y266 R286 S288 R291 Q294 W295 A296 Q308 T309 I310 Y229 R249 S251 R254 Q257 W258 A259 Q271 T272 I273
External links
PDB RCSB:8vw5, PDBe:8vw5, PDBj:8vw5
PDBsum8vw5
PubMed38894924
UniProtQ13191|CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (Gene Name=CBLB)

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