Structure of PDB 8vw4 Chain A

Receptor sequence
>8vw4A (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
QAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRL
ILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQS
QDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFG
DKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFT
RLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRL
SCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSY
NPDL
3D structure
PDB8vw4 Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.
ChainA
Resolution2.4 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D221 N225 Y227 E232 D184 N188 Y190 E195
BS02 A1AEG A Y266 R286 S288 R291 Q294 A296 Q308 T309 I310 Y229 R249 S251 R254 Q257 A259 Q271 T272 I273
BS03 A1AEG A Q61 Y73 L75 P79 Q83 Q24 Y36 L38 P42 Q46
External links
PDB RCSB:8vw4, PDBe:8vw4, PDBj:8vw4
PDBsum8vw4
PubMed38894924
UniProtQ13191|CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (Gene Name=CBLB)

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