Structure of PDB 8vw1 Chain A

Receptor sequence
>8vw1A (length=439) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
ADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAV
ERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCR
EAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDE
CELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLR
IYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHLNHQQGETWLRV
KGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLP
HRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSA
DFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPR
VQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELGGH
3D structure
PDB8vw1 Crystal Structure of Apo UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from E. coli (ADP bound)
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.9: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A N114 G115 K116 S117 T118 N179 H268 N272 R303 D318 K320 A321 S326 A329 N113 G114 K115 S116 T117 N178 H267 N271 R302 D317 K319 A320 S325 A328
BS02 CA A D36 T37 D35 T36
BS03 CA A Q387 T388 Q386 T387
BS04 CA A A415 S416 F423 A414 S415 F422
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
GO:0042802 identical protein binding
Biological Process
GO:0008360 regulation of cell shape
GO:0009058 biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:8vw1, PDBe:8vw1, PDBj:8vw1
PDBsum8vw1
PubMed
UniProtP14900|MURD_ECOLI UDP-N-acetylmuramoylalanine--D-glutamate ligase (Gene Name=murD)

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