Structure of PDB 8vsd Chain A

Receptor sequence
>8vsdA (length=593) Species: 9606 (Homo sapiens) [Search protein sequence]
FNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGI
VEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRS
KQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDAD
GQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVY
SIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTL
GMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLF
MDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDL
DQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSM
PPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVY
PSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLD
KLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRD
KLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHIL
3D structure
PDB8vsd Dynamic allostery drives autocrine and paracrine TGF-beta signaling
ChainA
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A N286 D288 Y290 D292 N286 D288 Y290 D292
BS02 CA A D349 D351 F355 D357 D349 D351 F355 D357
BS03 CA A D415 N417 Y419 D421 A437 D415 N417 Y419 D421 A437
BS04 CA A N232 D234 I236 D238 N232 D234 I236 D238
External links
PDB RCSB:8vsd, PDBe:8vsd, PDBj:8vsd
PDBsum8vsd
PubMed
UniProtP06756|ITAV_HUMAN Integrin alpha-V (Gene Name=ITGAV)

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