Structure of PDB 8vpi Chain A

Receptor sequence
>8vpiA (length=543) Species: 1496 (Clostridioides difficile) [Search protein sequence]
YTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILYDLF
EENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSLTNK
KVDESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLE
KYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLREY
IKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKNED
ICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEKC
KYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNINK
YIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRKW
YELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKEEY
LDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFRDN
NYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
3D structure
PDB8vpi Quinoline-based compounds can inhibit diverse enzymes that act on DNA
ChainA
Resolution2.89 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A I349 G351 C352 D353 K378 R425 Q438 W439 Y455 K456 I315 G317 C318 D319 K344 R391 Q404 W405 Y421 K422
BS02 dna A L226 Q346 I431 R432 W439 R441 Y476 Y521 N523 L192 Q312 I397 R398 W405 R407 Y442 Y487 N489
BS03 dna A S429 G430 I431 S395 G396 I397
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