Structure of PDB 8vme Chain A

Receptor sequence

>8vmeA (length=357) Species: 10090 (Mus musculus) [Search protein sequence]

QMKVSRDSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCD
SGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVY
LNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI
CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL
IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT
REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTA
RLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATIL
IPPHARH

3D structure

PDB

8vme Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3 beta.

Chain

Resolution

2.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	V263 D264 L266 Y288 F291 F293 P294	V236 D237 L239 Y261 F264 F266 P267
BS02	peptide	A	F67 R92 K94 R96 R180 K205 N213 V214 I217	F40 R65 K67 R69 R153 K178 N186 V187 I190
BS03	ADP	A	G65 F67 G68 A83 K85 D133 Y134 V135 L188 D200	G38 F40 G41 A56 K58 D106 Y107 V108 L161 D173
BS04	MG	A	N186 D200	N159 D173

External links

PDB	RCSB:8vme, PDBe:8vme, PDBj:8vme
PDBsum	8vme
PubMed	39226374
UniProt	Q9WV60\|GSK3B_MOUSE Glycogen synthase kinase-3 beta (Gene Name=Gsk3b)

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