Structure of PDB 8vl7 Chain A

Receptor sequence
>8vl7A (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
GPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTPPTVPPPPR
VVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFL
RRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKAL
ERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRP
QALLRWVDAHARPFGTIRPMYG
3D structure
PDB8vl7 Co-crystal structure of human TREX1 in complex with an inhibitor
ChainA
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1ACJ A D18 M19 E20 A21 L24 I84 Y129 L133 M232 D10 M11 E12 A13 L16 I72 Y117 L121 M220
BS02 MG A D18 E20 D200 D10 E12 D188
BS03 MG A D18 M19 D130 D10 M11 D118
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:8vl7, PDBe:8vl7, PDBj:8vl7
PDBsum8vl7
PubMed
UniProtQ9NSU2|TREX1_HUMAN Three-prime repair exonuclease 1 (Gene Name=TREX1)

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