Structure of PDB 8vkz Chain A

Receptor sequence
>8vkzA (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
TPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQMIAAVKWA
KAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLI
INEQRPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLK
SQELFDEIRMTYIKELGKAIVSQNWQRFYQLTKLLDSMHEVVENLLNYCF
QTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
3D structure
PDB8vkz Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties
ChainA
Resolution2.133 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I572 V575 K579 R585 M593 Q597 M752 E755 I44 V47 K51 R57 M65 Q69 M215 E218
BS02 A1ACE A L563 N564 Q570 M601 M604 F623 M639 C643 M646 Y735 C736 T739 L35 N36 Q42 M73 M76 F95 M108 C112 M115 Y198 C199 T202
External links
PDB RCSB:8vkz, PDBe:8vkz, PDBj:8vkz
PDBsum8vkz
PubMed38516584
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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