Structure of PDB 8vkj Chain A

Receptor sequence
>8vkjA (length=548) Species: 9606 (Homo sapiens) [Search protein sequence]
ELKMDQALLLIHNELLWTNLTVYWKSECCYHCLFQVLVNVPQSPKAGKPS
AAAASVSTQHGSILQLNDTLEEKEVCRLEYRFGEFGNYSLLVKNIHEIAC
DLAVNEDPVDSNLPVSIAFLIGLAVIIVISFLRLLLSLDDFNNWISKAIP
PRLRSVDTFRGIALILMVFVNYGGGKYWYFKHASWNGLTVADLVFPWFVF
IMGSSIFLSMTSILQRGCSKFRLLGKIAWRSFLLICIGIIIVNPNYCLGP
LSWDKVRIPGVLQRLGVTYFVVAVLELLFAKPVPEHCASERSCLSLRDIT
SSWPQWLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGG
AAGYIDRLLLGDDHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGV
QAGKILLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNL
WSLSYVTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHE
VFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRKKIFWKI
3D structure
PDB8vkj Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome
ChainA
Resolution2.92 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A R267 L268 D272 R275 M282 N286 V309 F313 M317 S320 R345 V376 L380 S607 Y611 K662 R152 L153 D157 R160 M167 N171 V194 F198 M202 S205 R230 V261 L265 S492 Y496 K547
Gene Ontology
Molecular Function
GO:0015019 heparan-alpha-glucosaminide N-acetyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0007041 lysosomal transport
GO:0030200 heparan sulfate proteoglycan catabolic process
GO:0051259 protein complex oligomerization
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0035579 specific granule membrane
GO:0043202 lysosomal lumen
GO:0070821 tertiary granule membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8vkj, PDBe:8vkj, PDBj:8vkj
PDBsum8vkj
PubMed
UniProtQ68CP4|HGNAT_HUMAN Heparan-alpha-glucosaminide N-acetyltransferase (Gene Name=HGSNAT)

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