Structure of PDB 8vka Chain A

Receptor sequence

>8vkaA (length=384) Species: 126793 (Plasmodium vivax Sal-1)

DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVC
DVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWH
IGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAP
VLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGF
SSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFN
LYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDK
YSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVF
EDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL

3D structure

• PDB: 8vka Exploring Subsite Selectivity within Plasmodium vivax N -Myristoyltransferase Using Pyrazole-Derived Inhibitors.
• Chain: A
• Resolution: 1.97 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MYA	A	Y28 K29 F30 W31 Y95 V96 L163 V165 R170 S171 R173 A175 P176 I179 T183 I186 W192 Q193 A194 Y196 T197 L202 Y393	Y2 K3 F4 W5 Y69 V70 L137 V139 R144 S145 R147 A149 P150 I153 T157 I160 W166 Q167 A168 Y170 T171 L176 Y367
BS02	A1AB7	A	V96 E97 F103 F105 T197 Y211 F226 S319 Y334 L367 L410	V70 E71 F77 F79 T171 Y185 F200 S293 Y308 L341 L384

Gene Ontology

Molecular Function

• GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0018008 N-terminal peptidyl-glycine N-myristoylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8vka, PDBe:8vka, PDBj:8vka
• PDBsum: 8vka
• PubMed: 38680035
• UniProt: A5K1A2