Structure of PDB 8vjv Chain A

Receptor sequence
>8vjvA (length=665) Species: 9606 (Homo sapiens) [Search protein sequence]
SSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQVYDAVGMLGIEEVTYEN
CLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMS
MRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNE
IKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTDDD
KYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLPLR
TKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFI
LNLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIE
VVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYL
DLYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPVAGRPSLL
RHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVW
DVDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQS
LHTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYL
WSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLK
REPNQKAFLMSRGLH
3D structure
PDB8vjv Structural basis of divergent substrate recognition and inhibition of human neurolysin.
ChainA
Resolution2.12 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N180 Y423 H425 A426 A427 C428 T471 H474 E475 H478 R554 Q555 L558 T598 H601 Y610 Y613 N166 Y409 H411 A412 A413 C414 T457 H460 E461 H464 R540 Q541 L544 T584 H587 Y596 Y599
BS02 ZN A H474 H478 E503 H460 H464 E489
External links
PDB RCSB:8vjv, PDBe:8vjv, PDBj:8vjv
PDBsum8vjv
PubMed39117724
UniProtQ9BYT8|NEUL_HUMAN Neurolysin, mitochondrial (Gene Name=NLN)

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