Structure of PDB 8vie Chain A

Receptor sequence

>8vieA (length=367) Species: 9606 (Homo sapiens) [Search protein sequence]

IQCSQRMLSFSDALLSIIATVMILPVTHTEISPEQQFDRSVQRLLATRIA
VYLMTFLIVTVAWAAHTRLFQVVGKTDDTLALLNLACMMTITFLPYTFSL
MVTFPDVPLGIFLFCVCVIAIGVVQALIVGYAFHFPHLLSPQIQEPLSKE
RVEAFSDGVYAIVATLLILDICEDNVPDPKDVKERFSGSLVAALSATGPR
FLAYFGSFATVGLLWFAHHSLFLHVRKATRAMGLLNTLSLAFVGGLPLAY
QQTSAFARQPRDELERVRVSCTIIFLASIFQLAMWTTALLHQAETLQPSV
WFGGREHVLMFAKLALYPCASLLAFASTCLLSRFSVGIFHLMQIAVPCAF
LLLRLLVGLALATLRVL

3D structure

PDB

8vie Structure of human TMEM175 in an inhibitor-bound state

Chain

Resolution

3.52 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1AB0	A	A42 I46 G267	A13 I17 G158

External links

PDB	RCSB:8vie, PDBe:8vie, PDBj:8vie
PDBsum	8vie
PubMed
UniProt	Q9BSA9\|TM175_HUMAN Endosomal/lysosomal proton channel TMEM175 (Gene Name=TMEM175)

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