Structure of PDB 8vic Chain A

Receptor sequence

>8vicA (length=358) Species: 9606 (Homo sapiens) [Search protein sequence]

IQCSQRMLSFSDALLSIIATVMILPVTHTEIDRSVQRLLATRIAVYLMTF
LIVTVAWAAHTRLFQVVGKTDDTLALLNLACMMTITFLPYTFSLMVTFPD
VPLGIFLFCVCVIAIGVVQALIVGYAFHFPHLLSPQIQEPLSKERVEAFS
DGVYAIVATLLILDICEDNVPDPKDVKERFSGSLVAALSATGPRFLAYFG
SFATVGLLWFAHHSLFLHVRKATRAMGLLNTLSLAFVGGLPLAYQQTSAF
ARQPRDELERVRVSCTIIFLASIFQLAMWTTALLHQAETLQPSVWFGGRE
HVLMFAKLALYPCASLLAFASTCLLSRFSVGIFHLMQIAVPCAFLLLRLL
VGLALATL

3D structure

PDB

8vic Structure of human TMEM175 in an inhibitor-bound state

Chain

Resolution

3.48 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1AA3	A	L53 H57 D279 E282	L24 H28 D164 E167

External links

PDB	RCSB:8vic, PDBe:8vic, PDBj:8vic
PDBsum	8vic
PubMed
UniProt	Q9BSA9\|TM175_HUMAN Endosomal/lysosomal proton channel TMEM175 (Gene Name=TMEM175)

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