Structure of PDB 8vby Chain A

Receptor sequence
>8vbyA (length=553) Species: 9606 (Homo sapiens) [Search protein sequence]
QDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMV
IAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYN
VIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPNDTFGTTPAAEYF
ERGVLHLHQSHGIDDLGPPRWQLTACLVLVYVLLYFSLWKGVKTSGKVVW
ITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQ
VCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSF
LGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLT
LGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNG
GIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPS
LYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATS
SMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHW
LKV
3D structure
PDB8vby Structure of the human dopamine transporter and mechanisms of inhibition
ChainA
Resolution3.19 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 42L A F76 D79 V152 Y156 F326 S422 F19 D22 V95 Y99 F259 S355
BS02 A1AAF A L80 V83 W84 V364 K384 G386 I390 Y394 L23 V26 W27 V297 K317 G319 I323 Y327
BS03 Y01 A L70 I352 L13 I285
BS04 Y01 A M111 S354 M54 S287
BS05 ZN A D191 H193 H375 E396 D134 H136 H308 E329
BS06 Y01 A F253 V265 F186 V198
External links
PDB RCSB:8vby, PDBe:8vby, PDBj:8vby
PDBsum8vby
PubMed39112705
UniProtQ01959|SC6A3_HUMAN Sodium-dependent dopamine transporter (Gene Name=SLC6A3)

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