Structure of PDB 8va1 Chain A

Receptor sequence
>8va1A (length=559) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
KSKIYIDKIYWERVQLFVEGHSENLDLEDSNFVLRNLTETRTMKANDVKI
DGNQFVCRFNVAILDNGYYLPEDKYLLVNEQELDYIAQLNPDVINDAYQN
LKPEQEEEYNELETQNGKINFLLQTYLKEFRKGGISKKTVYTVTPEISSD
VNEFVLDVVVTTPEVKSIYIVRKYKELRKYFRKQSFNTRQFIFKAIFNTT
KFFHLKKGNTVLFTSDSRPTMSGNFEYIYNEMLRQNLDKKYDIHTVFKAN
ITDRRGIIDKFRLPYLLGKADYIFVDDFHPLIYTVRFRRSQEVIQVWNAV
GAFKTVGFSRTGKKGGPFIDSLNHRSYTKAYVSSETDIPFYAEAFGIKEK
NVVPTGVPRTDVLFDEAYATQIKQEMEDELPIIKGKKVILFAPTFRGSGH
GTAHYPFFKIDFERLARYCEKNNAVVLFKMHPFVKNRLNIADKHKQYFVD
VSDFREVNDILFITDLLISDYSSLIYEYAVFKKPMIFYAFDLEDYITTRD
FYEPYESFVPGKIVQSFDALMDALDNEDYEGEKVIPFLDKHFKYQDGRSS
ERLVRNLFG
3D structure
PDB8va1 Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.8.14: CDP-ribitol ribitolphosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V2V A W299 A301 G303 F305 K306 V308 Y343 K431 H433 P434 V459 S474 S475 W297 A299 G301 F303 K304 V306 Y341 K429 H431 P432 V457 S472 S473
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0047355 CDP-glycerol glycerophosphotransferase activity
GO:0047356 CDP-ribitol ribitolphosphotransferase activity
Biological Process
GO:0019350 teichoic acid biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8va1, PDBe:8va1, PDBj:8va1
PDBsum8va1
PubMed38416829
UniProtQ2G1B8|TARL_STAA8 Teichoic acid ribitol-phosphate polymerase TarL (Gene Name=tarL)

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