Structure of PDB 8v9g Chain A

Receptor sequence
>8v9gA (length=265) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
EKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFP
LAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQ
AAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTP
GDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAG
FPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDE
LVASVGQVITQLILS
3D structure
PDB8v9g Restricted Rotational Flexibility of the C5 alpha-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase.
ChainA
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MER A S64 W99 S125 N127 E161 S165 T230 G231 T232 S45 W80 S106 N108 E142 S146 T211 G212 T213
BS02 MG A G92 P93 D94 G73 P74 D75
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8v9g, PDBe:8v9g, PDBj:8v9g
PDBsum8v9g
PubMed38511828
UniProtQ09HD0|BLAG5_KLEPN Beta-lactamase GES-5 (Gene Name=blaGES-5)

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