Structure of PDB 8v7h Chain A

Receptor sequence

>8v7hA (length=425) Species: 9606 (Homo sapiens) [Search protein sequence]

GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSGTEWSPPLTMLFLCATKFSAS

3D structure

PDB

8v7h Human DNA polymerase eta-DNA-araC-ended primer ternary complex:ground state at pH7.0 (K+ MES) with 1 Ca2+ ion

Chain

Resolution

1.68 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Q38 Y39 W42 K86 L89 R93 K311 P316 K317 T318 G320 S322 K323 N324 P326 G327 R351	Q41 Y42 W45 K89 L92 R96 K306 P311 K312 T313 G315 S317 K318 N319 P321 G322 R346
BS02	dna	A	E116 K224 S257 G259 G260 K261 L262 R377 R382 R383 C384	E119 K219 S252 G254 G255 K256 L257 R372 R377 R378 C379
BS03	CA	A	D13 M14 D115	D16 M17 D118
BS04	DTP	A	D15 C16 F17 F18 I48 Y52 R55 R61 D115	D18 C19 F20 F21 I51 Y55 R58 R64 D118

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8v7h, PDBe:8v7h, PDBj:8v7h
PDBsum	8v7h
PubMed
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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