Structure of PDB 8v7b Chain A

Receptor sequence

>8v7bA (length=430) Species: 9606 (Homo sapiens) [Search protein sequence]

GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRA
AIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPI
RKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMC
RGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERL
TKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTV
IKNCNTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

PDB

8v7b Human DNA polymerase eta-DNA-dT primer araCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion

Chain

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Q38 Y39 W42 R61 S62 K86 R93 K293 R313 P316 K317 T318 G320 C321 S322 K323 N324 P326 G327	Q41 Y42 W45 R64 S65 K89 R96 K291 R311 P314 K315 T316 G318 C319 S320 K321 N322 P324 G325
BS02	dna	A	S113 K224 S257 G259 G260 K261 L262 R377 R382	S116 K222 S255 G257 G258 K259 L260 R375 R380
BS03	HF4	A	D13 D15 C16 F17 F18 I48 Y52 R55 R61 D115 K231	D16 D18 C19 F20 F21 I51 Y55 R58 R64 D118 K229
BS04	CA	A	D13 M14 D115	D16 M17 D118

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8v7b, PDBe:8v7b, PDBj:8v7b
PDBsum	8v7b
PubMed
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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