Structure of PDB 8v54 Chain A

Receptor sequence
>8v54A (length=959) Species: 9606 (Homo sapiens) [Search protein sequence]
GQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQP
AVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKP
PAWAWAEGWTRYGPEGEAVPVAIPEERALVFAVAVCLAEGTCPTLAVAIS
PSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTDWQEQLVVGHNVSFD
RAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGISSWDW
LDISSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCA
QDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAE
AQGTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQ
KEDLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKL
CPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPG
RRDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKM
EDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRA
VIRHPDYDEEGLYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSEL
KAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGR
KSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHRLT
QQEAAEKAQQMYAATKGLRWYRRAWKGGTESEMFNKLESIATSDIPRTPV
LGCCISRALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFA
IDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLP
QSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQII
ELTKGSLEK
3D structure
PDB8v54 Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis.
ChainA
Resolution4.1 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R579 H754 G763 A767 K768 L860 T861 S863 R869 D1135 R453 H530 G539 A543 K544 L636 T637 S639 R645 D861
BS02 dna A S306 K561 S593 M596 R597 R807 T849 I850 Y955 S232 K435 S467 M470 R471 R583 T625 I626 Y731
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0045004 DNA replication proofreading
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0000262 mitochondrial chromosome
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005760 gamma DNA polymerase complex
GO:0032991 protein-containing complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8v54, PDBe:8v54, PDBj:8v54
PDBsum8v54
PubMed38932681
UniProtP54098|DPOG1_HUMAN DNA polymerase subunit gamma-1 (Gene Name=POLG)

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