Structure of PDB 8v4s Chain A

Receptor sequence
>8v4sA (length=552) Species: 10114 (Rattus) [Search protein sequence]
SWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKE
PLISSVHTKVKGVAEVTELVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQ
EQKLCPEYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEI
FAWCPAEEGKEAPRPALLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNI
SCTFHKTWNPQCPIFRLGDIFQEIGENFTEVAVQGGIMGIEIYWDCNLDS
WSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYKENGMEKRTLIKAFG
VRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYASTCCR
SRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQ
QLLGKSLQDVKGQEVPRPQTDFLELSRLDSPDWCQCGNCLPSQLPENRRA
LEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEAINS
KLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKY
PY
3D structure
PDB8v4s High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket
ChainA
Resolution2.49 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A R546 H547 Y550 A567 I568 L569 R574 K583 Y588 S589 G590 F591 R503 H504 Y507 A524 I525 L526 R531 K540 Y545 S546 G547 F548
BS02 ZN A C479 C499 C506 C572 C436 C456 C463 C529
BS03 ZN A C477 C479 C482 C434 C436 C439
External links
PDB RCSB:8v4s, PDBe:8v4s, PDBj:8v4s
PDBsum8v4s
PubMed39107314
UniProtQ64663|P2RX7_RAT P2X purinoceptor 7 (Gene Name=P2rx7)

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