Structure of PDB 8v3k Chain A

Receptor sequence
>8v3kA (length=340) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence]
AVPPSLRLPVIEAAFPRQLHPYWPKLQETTRTWLLEKRLMPADKVEEYAD
GLCYTDLMAGYYLGAPDEVLQAIADYSAWSFVWDDRHDRDIVHGRAGAWR
RLRGLLHTALDSPGDHLHHEDTLVAGFADSVRRLYAFLPATWNARFARHF
HTVIEAYDREFHNRTRGIVPGVEEYLELRRLTSAHWIWTDLLEPSSGCEL
PDAVRKHPAYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHH
SLTLEEAIGEVRRRVEECITEFLAVERDALRFADELADGTVRGKELSGAV
RANVGNMRNWFSSVYWFHHESGRYMVDSWDDRSTPPYVNN
3D structure
PDB8v3k Structure-Based Engineering of a Terpene Cyclase to Generate a Sesquiterpene Alcohol: Conversion of epi-Isozizaene Synthase into an a-Bisabolol Synthase
ChainA
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.3.37: epi-isozizaene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N240 S244 E248 N225 S229 E233
BS02 DPO A D99 R194 N240 S244 K247 E248 R338 Y339 D84 R179 N225 S229 K232 E233 R323 Y324
BS03 BTM A F96 D99 T197 S198 W203 H333 F81 D84 T182 S183 W188 H318
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0052680 epi-isozizaene synthase activity

View graph for
Molecular Function
External links
PDB RCSB:8v3k, PDBe:8v3k, PDBj:8v3k
PDBsum8v3k
PubMed38420671
UniProtQ9K499|CYC1_STRCO Epi-isozizaene synthase (Gene Name=cyc1)

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