Structure of PDB 8v2f Chain A

Receptor sequence
>8v2fA (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
TRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAV
KKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVY
VYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDI
KSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRG
EITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIED
YIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA
3D structure
PDB8v2f Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
ChainA
Resolution2.09 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YJU A I185 M192 V200 A211 Y262 V263 Y264 M265 P266 G268 L318 I23 M30 V38 A49 Y100 V101 Y102 M103 P104 G106 L156
External links
PDB RCSB:8v2f, PDBe:8v2f, PDBj:8v2f
PDBsum8v2f
PubMed38920289
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

[Back to BioLiP]