Structure of PDB 8uzh Chain A

Receptor sequence
>8uzhA (length=605) Species: 83332,559292 [Search protein sequence]
INLKVSDEIFRLMEAFAKRQGKEMDSEDDIIEQGSHVEGGVVEHPDAKDF
GSAAALPADPTWFKHAVFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWL
GIDCIWLPPFYDSPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGI
RIITDLVMNHTSESHPWFQESRRDPDGPYGDYYVWSDTSERYTDARIIFV
DTEESNWSFDPVRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVIRFWLGLG
IDGFRLDAVPYLFEREGTNCENLPETHAFLKRVRKVVDDEFPGRVLLAEA
NQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFMAVRRESRFPISEIIA
QTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMKANVGI
RRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYGDEIGMGDVIWLGDRDG
VRIPMQWTPDRNAGFSTANPGRLYLPPSQDPVYGYQAVNVEAQRDTSTSL
LNFTRTMLAVRRRHPAFAVGAFQELGGSNPSVLAYVRQVAGDDGDTVLCV
NNLSRFPQPIELDLQQWTNYTPVELTGHVEFPRIGQVPYLLTLPGHGFYW
FQLTT
3D structure
PDB8uzh Targeting Mycobacterium tuberculosis Persistence through Inhibition of the Trehalose Catalytic Shift.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
3.2.1.1: alpha-amylase.
5.4.99.16: maltose alpha-D-glucosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D157 S159 D161 D82 S84 D86
BS02 CA A N234 D302 Y336 L337 E339 N159 D227 Y261 L262 E264
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004556 alpha-amylase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016161 beta-amylase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016853 isomerase activity
GO:0031386 protein tag activity
GO:0042802 identical protein binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0046872 metal ion binding
GO:0047471 maltose alpha-D-glucosyltransferase activity
Biological Process
GO:0000023 maltose metabolic process
GO:0000272 polysaccharide catabolic process
GO:0005975 carbohydrate metabolic process
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0005991 trehalose metabolic process
GO:0005992 trehalose biosynthetic process
GO:0016925 protein sumoylation
GO:0045227 capsule polysaccharide biosynthetic process
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005940 septin ring

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8uzh, PDBe:8uzh, PDBj:8uzh
PDBsum8uzh
PubMed38485491
UniProtP9WQ19|TRES_MYCTU Trehalose synthase/amylase TreS (Gene Name=treS);
Q12306|SMT3_YEAST Ubiquitin-like protein SMT3 (Gene Name=SMT3)

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