Structure of PDB 8uy1 Chain A

Receptor sequence
>8uy1A (length=598) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
SNAMHIRDMLAEAERTGEPSFSFQYFPPKTAQGVQNLYDRMERMYNYGPK
FIDITWGAGGRVAELTCEMVVQAQAYLGLETCMHLTCTDMGVERINDALR
KAYKAGCTNILALRGDPPRDKEKWEAAKDGFRYAKDLVAHIRKEYGDHFD
IGVAGYPEGCDDNKDEDLLLDHLKEKVDMGAGFIVTQMFYDVDNFLRWVK
KVRERGISVPIVPGIMPIATYASFLRRANHMKCKIPEEWMAKLEPVKNDD
VAVREIGKTLVADMCRKILDAGIRHLHFYTMNLAQATRMVLEELNWLPSP
DRPLKHALPWKQSLGFGRRGEDVRPIFWRNRNKSYVARTQDWDEFPNGRW
GDSRSPAFGELDAYGVGLTGSNEQNRERWGEPKCIRDIANLFIRYMRKEI
DYLPWSEAPVADEADLIKDELIDLNRRGLITVNSQPAVNGAKSNHPVHGW
GPSNGYVYQKAYLEFFVSPELYPEIKRRIESHPDLTYHAVTKSGNLETNA
QSDGPNAVTWGVFPGKEIFQPTIVERISFLAWKDEAYHLGMEWARCYDAG
SPSRVLLEEMMNTWWLVNIVNNDFHQGNTLFEILKGLEVTDLDKVPET
3D structure
PDB8uy1 Structural basis of S-adenosylmethionine-dependent allosteric transition from active to inactive states in methylenetetrahydrofolate reductase.
ChainA
Resolution3.49 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A T52 W53 H81 T83 L110 R111 G112 D113 Y130 A131 Y153 H169 E172 K173 V182 T55 W56 H84 T86 L113 R114 G115 D116 Y133 A134 Y156 H172 E175 K176 V185
Gene Ontology
Molecular Function
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0016491 oxidoreductase activity
GO:0071949 FAD binding
Biological Process
GO:0009086 methionine biosynthetic process
GO:0035999 tetrahydrofolate interconversion
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uy1, PDBe:8uy1, PDBj:8uy1
PDBsum8uy1
PubMed38886362
UniProtG0S5U9

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