Structure of PDB 8uxw Chain A

Receptor sequence
>8uxwA (length=400) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence]
ASFNVPIIMDNGTGYSKLGYAGNDAPSYVFPTVIATRSKRATEDLDFFIG
NDALKKASAGYSLDYPIRHGQIENWDHMERFWQQSLFKYLRCEPEDHYFL
LTEPPLNPPENRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVTDR
SLTGTVVDSGDGVTHIIPVAEGYVIGSSIKTMPLAGRDVTYFVQSLLRDR
NEPDSSLKTAERIKEECCYVCPDIVKEFSRFDREPDRYLKYASESITGHS
TTIDVGFERFLAPEIFFNPEIASSDFLTPLPELVDNVVQSSPIDVRKGLY
KNIVLSGGSTLFKNFGNRLQRDLKRIVDERIHRSEMLSGAKSGGVDVNVI
SHKRQRNAVWFGGSLLAQTPEFGSYCHTKADYEEYGASIARRYQIFGNSL
3D structure
PDB8uxw High resolution cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by the Arp2/3 complex
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G13 T14 G15 Y16 K18 G187 D188 G213 K241 E242 G334 G335 F339 R383 G12 T13 G14 Y15 K17 G160 D161 G186 K214 E215 G307 G308 F312 R356
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0006897 endocytosis
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0044396 actin cortical patch organization
GO:0090135 actin filament branching
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0030479 actin cortical patch
GO:0032153 cell division site
GO:0051285 cell cortex of cell tip

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uxw, PDBe:8uxw, PDBj:8uxw
PDBsum8uxw
PubMed38448439
UniProtP32390|ARP3_SCHPO Actin-related protein 3 (Gene Name=act2)

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