Structure of PDB 8uxs Chain A

Receptor sequence

>8uxsA (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]

CPAERSGHVAVSDGRHMFVWGGYKSNDFYLPREELWIYNMETGRWKKINT
EGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRVLQWERIDC
QGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDVLGTFEFDETSFWNSSHP
RGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYR
DARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFT
TDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGC
ANNLLVHHRAAHSNEILIFSV

3D structure

PDB

8uxs KLHDC2 ubiquitin ligase in complex with a novel small-molecule

Chain

Resolution

2.0 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	XU8	A	K147 Y163 A219 R236 R241 S269 W270 L342 L343 H345	K110 Y126 A181 R198 R203 S231 W232 L304 L305 H307

External links

PDB	RCSB:8uxs, PDBe:8uxs, PDBj:8uxs
PDBsum	8uxs
PubMed
UniProt	Q9Y2U9\|KLDC2_HUMAN Kelch domain-containing protein 2 (Gene Name=KLHDC2)

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