Structure of PDB 8uw9 Chain A

Receptor sequence
>8uw9A (length=388) Species: 9606 (Homo sapiens) [Search protein sequence]
DVAIVKEGWLHKRGKYIKTWRPRYFLLKNDGTFIGYKERPQDEAPLNNFS
VAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTV
ADGLKKQEEEEMDASAEHTDMERVTMNEFEYLKLLGKGTFGKVILVKEKA
TGRYYAMKILKKEVIVRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGG
ELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD
KDGHIKITDFGLCKEGITFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMY
EMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQ
RLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQ
3D structure
PDB8uw9 Mutant-selective AKT1 inhibitors via lysine targeting and neo-zinc chelation
ChainA
Resolution1.9 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XQ2 A K17 N53 Q79 W80 I84 L210 T211 Y272 R273 I290 D292 C310 K15 N47 Q73 W74 I78 L177 T178 Y239 R240 I257 D259 C270
BS02 ZN A K17 C296 C310 K15 C263 C270
External links
PDB RCSB:8uw9, PDBe:8uw9, PDBj:8uw9
PDBsum8uw9
PubMed
UniProtP31749|AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (Gene Name=AKT1)

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