Structure of PDB 8uw7 Chain A

Receptor sequence
>8uw7A (length=399) Species: 9606 (Homo sapiens) [Search protein sequence]
DVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDPLNNFSVA
QCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVAD
GLKKQEEEEMDASAEHTDMERVTMNEFEYLKLLGKGTFGKVILVKEKATG
RYYAMKILKKEVIVAKDETENRVLQNSRHPFLTALKYSFQTHDRLCFVME
YANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLE
NLMLDKDGHIKITDFGLCKEGTPEYLAPEVLEDNDYGRAVDWWGLGVVMY
EMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQ
RLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD
3D structure
PDB8uw7 Mutant-selective AKT1 inhibitors via lysine targeting and neo-zinc chelation
ChainA
Resolution1.972 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XOO A Y18 N53 Q79 W80 L210 T211 L264 V270 Y272 R273 I290 D292 X296 K297 Y16 N45 Q71 W72 L182 T183 L236 V242 Y244 R245 I262 D264 X268 K269
External links
PDB RCSB:8uw7, PDBe:8uw7, PDBj:8uw7
PDBsum8uw7
PubMed
UniProtP31749|AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (Gene Name=AKT1)

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