Structure of PDB 8uw3 Chain A

Receptor sequence
>8uw3A (length=1265) Species: 9606 (Homo sapiens) [Search protein sequence]
SHITILTLNINGLNSAIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLK
IKGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQ
QEELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGDFNTPLSTLDR
STRQKVNKDTQELNSALHQADLIDIYRTLHPKSTEYTFFSAPHHTYSKID
HIVGSKALLSKCKRTEIITNYLSDHSAIKLELRIKNSTTWKLNNLLLNDY
WVHNEMKAEIKMFFETNENKDTTYQNLWDAFKAVCRGKFIALNAHKRKQE
RSKIDTLTSQLKELEKQEQTHSKASRRQEITKIRAELKEIETQKTLQKIN
ESRSWFFERINKIDRPLARLIKKKREKNQIDTIKNDKGDITTDPTEIQTT
IREYYKHLYANKLENLEEMDKFLDTYTLPRLNQEEVESLNRPITGSEIVA
IINSLPTKKSPGPDGFTAEFYQRYKEELVPFLLKLFQSIEKEGILPNSFY
EASIILIPKPGRDTTKKENFRPISLMNIDAKILNKILANRIQQHIKKLIH
HDQVGFIPGMQGWFNIRKSINVIQHINRAKDKNHMIISIDAEKAFDKIQQ
PFMLKTLNKLGIDGTYFKIIRAIYDKPTANIILNGQKLEAFPLKTGTRQG
CPLSPLLFNIVLEVLARAIRQEKEIKGIQLGKEEVKLSLFADDMIVYLEN
PIVSAQNLLKLISNFSKVSGYKINVQKSQAFLYTNNRQTESQIMGELPFT
IASKRIKYLGIQLTRDVKDLFKENYKPLLKEIKEETNKWKNIPCSWVGRI
NIVKMAILPKVIYRFNAIPIKLPMTFFTELEKTTLKFIWNQKRARIAKSI
LSQKNKAGGITLPDFKLYYKATVTKTAWYWYQNRDIDQWNRTEPSEIMPH
IYNYLIFDKPEKNKQWGKDSLFNKWCWENWLAICRKLKLDPFLTPYTKIN
SRWIKDLNVKPKTIKTLEENLGITIQDIGVGKDFMSKTPKAMATKDKIDK
WDLIKLKSFCTAKETTIRVNRQPTTWEKIFATYSSDKGLISRIYNELKQI
YKKKTNNPIKKWAKDMNRHFSKEDIYAAKKHMKKCSSSLAIREMQIKTTM
RYHLTPVRMAIIKKSGNNRCWRGCGEIGTLLHCWWDCKLVQPLWKSVWRF
LRDLELEIPFDPAIPLLGIYPNEYKSCCYKDTCTRMFIAALFTIAKTWNQ
PKCPTMIDWIKKMWHIYTMEYYAAIKNDEFISFVGTWMKLETIILSKLSQ
EQKTKHRIFSLIGGN
3D structure
PDB8uw3 Template and target site recognition by human LINE-1 in retrotransposition
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.21.-
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0003964 RNA-directed DNA polymerase activity
GO:0004519 endonuclease activity
GO:0009036 type II site-specific deoxyribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process
GO:0006310 DNA recombination
GO:0032197 retrotransposition
GO:0090304 nucleic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8uw3, PDBe:8uw3, PDBj:8uw3
PDBsum8uw3
PubMed38096901
UniProtO00370|LORF2_HUMAN LINE-1 retrotransposable element ORF2 protein

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