Structure of PDB 8uvz Chain A

Receptor sequence
>8uvzA (length=160) Species: 1423 (Bacillus subtilis) [Search protein sequence]
MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESI
GRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQL
YTDLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPY
DYEFLMYEKK
3D structure
PDB8uvz Bacillus subtilis DHFR bound to NADP+ and folate
ChainA
Resolution0.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A F6 A7 I14 N18 D19 L20 G43 R44 K45 T46 V62 T63 S64 L79 I95 G97 A98 Q99 L100 R124 F6 A7 I14 N18 D19 L20 G43 R44 K45 T46 V62 T63 S64 L79 I95 G97 A98 Q99 L100 R124
Gene Ontology
Molecular Function
GO:0004146 dihydrofolate reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0046452 dihydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:8uvz, PDBe:8uvz, PDBj:8uvz
PDBsum8uvz
PubMed
UniProtP11045|DYR_BACSU Dihydrofolate reductase (Gene Name=dfrA)

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