Structure of PDB 8uvy Chain A

Receptor sequence

>8uvyA (length=396) Species: 9606 (Homo sapiens) [Search protein sequence]

DVAIVKEGWLHKRGKYIKTWRPRYFLLKNDGTFIGYKERPQDEAPLNNFS
VAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTV
ADGLKKQEEEEMDASAEHTDMEVTMNEFEYLKLLGKGTFGKVILVKEKAT
GRYYAMKILKKEVIVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELF
FHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG
HIKITDFGLCKEGITFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM
CGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG
GGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD

3D structure

PDB

8uvy Mutant-selective AKT1 inhibitors via lysine targeting and neo-zinc chelation

Chain

Resolution

2.11 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	XOO	A	K17 Q79 W80 L210 T211 V270 Y272 R273 I290 D292 C296 C310	K15 Q73 W74 L174 T175 V234 Y236 R237 I254 D256 C260 C267
BS02	ZN	A	K17 C296 C310	K15 C260 C267

External links

PDB	RCSB:8uvy, PDBe:8uvy, PDBj:8uvy
PDBsum	8uvy
PubMed
UniProt	P31749\|AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (Gene Name=AKT1)

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