Structure of PDB 8uvl Chain A

Receptor sequence
>8uvlA (length=403) Species: 9606 (Homo sapiens) [Search protein sequence]
SVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADR
EVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL
GLEPITLLQQTTSGLAHLHSLNIVHRNLKPHNILISMPNAHGKIKAMISD
FGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAG
CVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEK
MIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQ
LERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHY
RELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYY
FHE
3D structure
PDB8uvl Discovery of Potent, Selective, and Orally Available IRE1 alpha Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model.
ChainA
Resolution2.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.1.26.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XOE A V586 A597 K599 I640 I642 C645 A646 A647 E651 D711 F712 V25 A36 K38 I79 I81 C84 A85 A86 E90 D150 F151
External links
PDB RCSB:8uvl, PDBe:8uvl, PDBj:8uvl
PDBsum8uvl
PubMed38748820
UniProtO75460|ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 (Gene Name=ERN1)

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