Structure of PDB 8uv2 Chain A

Receptor sequence

>8uv2A (length=743) Species: 9606 (Homo sapiens) [Search protein sequence]

RPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIV
LSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDD
TVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPS
PYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVE
LPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLING
PEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVE
RRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGI
PDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQ
AIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEV
PQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPG
CGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAP
CVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIG
ATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVD
LEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQDPVPEIR
RDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPS

3D structure

PDB

8uv2 Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors.

Chain

Resolution

3.23 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ADP	A	I206 P247 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409	I185 P226 G227 T228 G229 K230 T231 L232 I359 H363 G387 A388
BS02	ADP	A	G480 P520 G521 C522 G523 K524 T525 I656 N660 G684 T688	G459 P499 G500 C501 G502 K503 T504 I635 N639 G663 T667
BS03	XKM	A	P496 V497 P500 F503 L504 G507 T509 P510 S511 K512 C535 A537 C572 K615 N616	P475 V476 P479 F482 L483 G486 T488 P489 S490 K491 C514 A516 C551 K594 N595

External links

PDB	RCSB:8uv2, PDBe:8uv2, PDBj:8uv2
PDBsum	8uv2
PubMed	39122922
UniProt	P55072\|TERA_HUMAN Transitional endoplasmic reticulum ATPase (Gene Name=VCP)

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