Structure of PDB 8uv1 Chain A

Receptor sequence
>8uv1A (length=435) Species: 9606 (Homo sapiens) [Search protein sequence]
NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWL
VKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGT
HHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHK
SGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGR
FQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKW
LCSEFKESMLTLGKESSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTA
EKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANL
SKAAWGALEKNGTQLMIRSYELGVLFLPSAFGLDSFKVKQKFFAGATFPV
PYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVP
3D structure
PDB8uv1 Structure of TDP1 complexed with compound IB01
ChainA
Resolution1.83 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XK6 A H263 S400 P461 N516 H102 S239 P294 N349
BS02 XK6 A Y204 H263 S399 S459 P461 H493 K495 N516 Y43 H102 S238 S292 P294 H326 K328 N349
BS03 XK6 A G308 H310 G147 H149
BS04 XK6 A P163 F164 F553 A568 T569 P2 F3 F386 A396 T397
External links
PDB RCSB:8uv1, PDBe:8uv1, PDBj:8uv1
PDBsum8uv1
PubMed
UniProtQ9NUW8|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

[Back to BioLiP]