Structure of PDB 8uuv Chain A

Receptor sequence
>8uuvA (length=307) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
VFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFY
VLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKW
ADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCN
KTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVM
YMGTLSYEQFKKGVQIPCTCQATKYLVQQESPFVMMSAPPAQYELKHGTF
TCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKEN
SYTTTIK
3D structure
PDB8uuv Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model
ChainA
Resolution3.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y2I A L162 G163 D164 E167 M208 P247 P248 Y264 Y268 Q269 L156 G157 D158 E161 M202 P239 P240 Y256 Y260 Q261
BS02 ZN A H89 K92 H83 K86
BS03 ZN A H89 D108 H83 D102
BS04 ZN A C111 H272 C105 H264
BS05 ZN A C189 C192 C224 C226 C183 C186 C218 C220
BS06 ZN A H17 E67 H11 E61
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8uuv, PDBe:8uuv, PDBj:8uuv
PDBsum8uuv
PubMed38547259
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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