Structure of PDB 8uuu Chain A

Receptor sequence
>8uuuA (length=305) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
VFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFY
VLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKW
ADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCN
KTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVM
YMGTLSYEQFKKGVQIPCTQATKYLVQQESPFVMMSAPPAQYELKHGTFT
CASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENS
YTTTI
3D structure
PDB8uuu Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model
ChainA
Resolution3.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XYR A L162 G163 D164 E167 M208 P248 Y264 Y268 Q269 L156 G157 D158 E161 M202 P239 Y255 Y259 Q260
BS02 ZN A W106 C111 H272 W100 C105 H263
BS03 ZN A C192 C224 C186 C218
BS04 ZN A H89 D108 H83 D102
BS05 ZN A H17 E67 H11 E61
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8uuu, PDBe:8uuu, PDBj:8uuu
PDBsum8uuu
PubMed38547259
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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