Structure of PDB 8urq Chain A

Receptor sequence
>8urqA (length=358) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
ALEGLRKKYKTRQELVKALTPKRRSIHLNSCSNADVLAHIKHFLSLAANS
LEQHQQPISIVFQNKKKHTTLDFPLNGPHLSTHQFKLKRCAILLNLLKVV
MEKLPLGKNTTVRDIFYSNVELFQRQANVVQWLDVIRFNFKLSPRKSLNI
IPAQKGLVYSPFPIDIYDNIQKQTIFSGKPCLIPFFQDDAVIKLGNIVIV
EKEAVFTKLVNNYHNTMLITGKGFPDFLTRLFLKKLEQYCSNLISDCSIF
TDADPYGISIALNYTHSNERNAYICTMANYKGIRITQVLAQNNESIQLLS
LNQRDYSLAKNLIASLTANSWDIATSPLKNVVIECQREIFFQKKAEMNEI
DAGIFKYK
3D structure
PDB8urq Cryo-EM structure of the yeast Spo11 core complex bound to DNA
ChainA
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K76 H101 R131 Q144 K173 E233 G259 F260 D262 F263 R266 R344 S347 K67 H83 R113 Q126 K155 E201 G223 F224 D226 F227 R230 R304 S307
BS02 MG A D288 D290 D252 D254
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005515 protein binding
GO:0045027 DNA end binding
GO:0046872 metal ion binding
Biological Process
GO:0000706 meiotic DNA double-strand break processing
GO:0007127 meiosis I
GO:0007129 homologous chromosome pairing at meiosis
GO:0007130 synaptonemal complex assembly
GO:0007131 reciprocal meiotic recombination
GO:0019953 sexual reproduction
GO:0030435 sporulation resulting in formation of a cellular spore
GO:0042138 meiotic DNA double-strand break formation
GO:0051321 meiotic cell cycle
Cellular Component
GO:0000228 nuclear chromosome
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0035861 site of double-strand break

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8urq, PDBe:8urq, PDBj:8urq
PDBsum8urq
PubMed
UniProtP23179|SPO11_YEAST Meiosis-specific protein SPO11 (Gene Name=SPO11)

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