Structure of PDB 8urb Chain A

Receptor sequence
>8urbA (length=921) Species: 28295 (Porcine epidemic diarrhea virus) [Search protein sequence]
DMAYLNRVRGSSAARLEPCNGTDTQHVYRAFDIYNKDVACLGKFLKVNCV
RLKNLDKHDAFYVVKRCTKSAMEHEQSIYSRLEKCGAVAEHDFFTWKDGR
AIYGNVCRKDLTEYTMMDLCYALRNFDENNCDVLKSILIKVGACEESYFN
NKVWFDPVENEDIHRVYALLGTIVSRAMLKCVKFCDAMVEQGIVGVVTLD
NQDLNGDFYDFGDFTCSIKGMGIPICTSYYSYMMPVMGMTNCLASECFVK
SDIFGEDFKSYDLLEYDFTEHKTALFNKYFKYWGLQYHPNCVDCSDEQCI
VHCANFNTLFSTTIPITAFGPLCRKCWIDGVPLVTTAGYHFKQLGIVWNN
DLNLHSSRLSINELLQFCSDPALLIASSPALVDQRTVCFSVAALGTGMTN
QTVKPGHFNKEFYDFLLEQGFFSEGSELTLKHFFFAQKGDAAVKDFDYYR
YNRPTVLDICQARVVYQIVQRYFDIYEGGCITAKEVVVTNLNKSAGYPLN
KFGKAGLYYESLSYEEQDELYAYTKRNILPTMTQLNLKYAISGKERARTV
GGVSLLSTMTTRQYHQKHLKSIVNTRGASVVIGTTKFYGGWDNMLKNLID
GVENPCLMGWDYPKCDRALPNMIRMISAMILGSKHTTCCSSTDRFFRLCN
ELAQVLTEVVYSNGGFYLKPGGTTSGDATTAYANSVFNIFQAVSANVNKL
LSVDSNVCHNLEVKQLQRKLYECCYRSTTVDDQFVVEYYGYLRKHFSMMI
LSDDGVVCYNNDYASLGYVADLNAFKAVLYYQNNVFMSASKCWIEPDINK
GPHEFCSQHTMQIVDKDGTYYLPYPDPSRILSAGVFVDDVVKTDAVVLLE
RYVSLAIDAYPLSKHENPEYKKVFYVLLDWVKHLYKTLNAGVLESFSVTL
LEDSTAKFWDESFYANMYEKS
3D structure
PDB8urb An alphacoronavirus polymerase structure reveals conserved co-factor functions.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A S754 D755 R831 K844 S856 S752 D753 R829 K842 S854
BS02 rna A K495 S496 K540 R564 K572 T587 F589 S677 G678 D679 A680 Y684 K493 S494 K538 R562 K570 T585 F587 S675 G676 D677 A678 Y682
BS03 ZN A H290 C296 H288 C294
BS04 ZN A H637 C640 H635 C638
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8urb, PDBe:8urb, PDBj:8urb
PDBsum8urb
PubMed36993498
UniProtU6BRU0

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