Structure of PDB 8uqc Chain A

Receptor sequence
>8uqcA (length=420) Species: 9606 (Homo sapiens) [Search protein sequence]
ECQCGICMEILVEPVTLPCNHTLCKPCFQSTVEKASLCCPFCRRRVSSWT
RYHTRRNSLVNVELWTIIQKHYPRECKLRASGSALKRINKELSDLARDPP
AQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVA
FTTRIYHPNINSNGSIKLDILRSQWSPALTISKVLLSICSLLCDPNPDDP
LVPEIARIYKTDRDKYNRISREWTQKYAMGGSGSGSRKESYSIYVYKVLK
QVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQT
AVRLLLPGELAKHAVSEGTKAVTKYTSSAKAKTRSSRAGLQFPVGRVHRL
LRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHL
QLAIRNDEELNKLLGRVTIA
3D structure
PDB8uqc Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 2)
ChainA
Resolution2.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.23: E2 ubiquitin-conjugating enzyme.
2.3.2.24: (E3-independent) E2 ubiquitin-conjugating enzyme.
2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C31 H33 C51 C19 H21 C39
BS02 ZN A C16 C19 C39 C4 C7 C27
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0019787 ubiquitin-like protein transferase activity
GO:0030527 structural constituent of chromatin
GO:0031625 ubiquitin protein ligase binding
GO:0046982 protein heterodimerization activity
GO:0061630 ubiquitin protein ligase activity
GO:0061631 ubiquitin conjugating enzyme activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000209 protein polyubiquitination
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
GO:0030514 negative regulation of BMP signaling pathway
GO:0036211 protein modification process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865 protein autoubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0085020 protein K6-linked ubiquitination
GO:1903955 positive regulation of protein targeting to mitochondrion
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uqc, PDBe:8uqc, PDBj:8uqc
PDBsum8uqc
PubMed38242129
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4);
P61077|UB2D3_HUMAN Ubiquitin-conjugating enzyme E2 D3 (Gene Name=UBE2D3);
Q16778|H2B2E_HUMAN Histone H2B type 2-E (Gene Name=H2BC21);
Q8IYW5|RN168_HUMAN E3 ubiquitin-protein ligase RNF168 (Gene Name=RNF168)

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