Structure of PDB 8unz Chain A

Receptor sequence

>8unzA (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]

DQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVGIF
ETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMRLQ
EALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLASKIEDYFPEFARYT
TPEDATPEPEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTE
NIRRVFNDCRDIIQRMHLRQYELL

3D structure

PDB

8unz Time-resolved cryo-EM of G protein activation by a GPCR

Chain

Resolution

3.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GTP	A	E50 G52 K53 S54 T55 K293 A366	E40 G42 K43 S44 T45 K126 A196

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0003925	G protein activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0010856	adenylate cyclase activator activity
GO:0016787	hydrolase activity
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031748	D1 dopamine receptor binding
GO:0046872	metal ion binding

	Biological Process
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0003091	renal water homeostasis
GO:0007165	signal transduction
GO:0007186	G protein-coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007608	sensory perception of smell
GO:0046907	intracellular transport
GO:0048589	developmental growth
GO:0050796	regulation of insulin secretion
GO:0050890	cognition
GO:0060348	bone development
GO:0060789	hair follicle placode formation
GO:0070527	platelet aggregation
GO:0071377	cellular response to glucagon stimulus
GO:0071380	cellular response to prostaglandin E stimulus
GO:0071870	cellular response to catecholamine stimulus
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0120162	positive regulation of cold-induced thermogenesis

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032588	trans-Golgi network membrane
GO:0070062	extracellular exosome

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8unz, PDBe:8unz, PDBj:8unz
PDBsum	8unz
PubMed	38480881
UniProt	P63092\|GNAS2_HUMAN Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Gene Name=GNAS)

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