Structure of PDB 8ulg Chain A

Receptor sequence
>8ulgA (length=827) Species: 9913 (Bos taurus) [Search protein sequence]
TAEEVEKFLDSNVSFAKQYYNLRYRAKVISDLLGPREAAVDFSNYHALNS
VEESEIIFDLLRDFQDNLQAEKCVFNVMKKLCFLLQADRMSLFMYRARNG
IAELATRLFNVHKDAVLEECLVAPDSEIVFPLDMGVVGHVALSKKIVNVP
NTEEDEHFCDFVDTLTEYQTKNILASPIMNGKDVVAIIMVVNKVDGPHFT
ENDEEILLKYLNFANLIMKVFHLSYLHNCETRRGQILLWSGSKVFEELTD
IERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAPPYAG
PRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNG
LICNIMNAPSEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFY
NRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYELMNKLENRKDIFQDMV
KYHVKCDNEEIQTILKTREVYGKEPWECEEEELAEILQGELPDADKYEIN
KFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYR
RITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHR
GTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQ
HEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLD
QTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQ
QNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITN
NRKEWKALADEYETKMKGLEEEKQKQQ
3D structure
PDB8ulg Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.
ChainA
Resolution3.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PCG A R93 M94 F113 N114 V140 C163 V166 Y172 M193 R89 M90 F109 N110 V136 C159 V162 Y168 M189
BS02 ZN A H563 H599 D600 H559 H595 D596
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0019933 cAMP-mediated signaling
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005886 plasma membrane
GO:0042622 photoreceptor outer segment membrane
GO:0042995 cell projection
GO:0097381 photoreceptor disc membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ulg, PDBe:8ulg, PDBj:8ulg
PDBsum8ulg
PubMed38159849
UniProtP11541|PDE6A_BOVIN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Gene Name=PDE6A)

[Back to BioLiP]