Structure of PDB 8uk6 Chain A

Receptor sequence
>8uk6A (length=573) Species: 5476 (Candida albicans) [Search protein sequence]
PERSMFSEGFLGDLHKPGEEPQMYPELLEEHKKFICDKVYTRFPPEPNGF
LHIGHSKAIMVNFGYAQFNKGNCYLRFDDTNPEAEEEVYFNSIKEMVSWL
GYKPWKITYSSDYFDELYELAIKLIKSDKAYICHCTPEEVKASRGLGERV
ACKHRFQTVEHNLREFENMKNGKYNVGEATLRMKQDLNSPSPQMWDLVAY
RVLNTPHHRTGDKWKIYPTYDFTHCLVDSFENITHSLCTTEFVLSRESYE
WLCDALHVYRPAQREYGRLNLTGTIMSKRKIAKLVNEGYVRGWDDPRLYT
LEGIKRRGVPPGAILSFINTLGVTTSTTNIQTVRFESAVRNYLDQTTPRL
MMVLHPIEVVIDNLDESFSLDVEIPYKPGKDEKSMGYRKLTFSKHIYIDE
NDVRAEPADKEFYRLAPGQPVGLMRVPFNISFKSIEEKDGKKIVHVNYDE
GVKAKPKTYIQWIPKDTAVHIKEVRIYNQLFKSENPSAHPEGYLKDINPD
SEEVLRNAVVEENLKDIVAKSPMNIEIPGSAFNIKENKGNNTVRFQALRE
GYFCLDKDSKEDGLILNRIVSLK
3D structure
PDB8uk6 Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-beta-thiophenylacrylamides exerts highly selective antifungal activity.
ChainA
Resolution2.73 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.1.1.18: glutamine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C372 H374 C152 H154
BS02 WVK A F263 H265 T494 I495 I501 Y519 T520 F50 H52 T274 I275 I281 Y299 T300
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004819 glutamine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006425 glutaminyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8uk6, PDBe:8uk6, PDBj:8uk6
PDBsum8uk6
PubMed38402621
UniProtA0A1D8PQM9

[Back to BioLiP]