Structure of PDB 8uh0 Chain A

Receptor sequence
>8uh0A (length=440) Species: 9606 (Homo sapiens) [Search protein sequence]
LRLPSPEVYRFVVKDSEENIVFIPIIKGGTVVKLIERLTYHMYADPNFVR
TFLTTYRSFCKPQELLSLLIERFEIPEPELKRFRKEYVQPVQLRILNVFR
HWVEHHFYDFERDLYLLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQ
ITFESPPPPIEWHISKPGHIETFDLMTLHPIEIARQLTLLESDLYRKVQP
SELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAV
LSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKIL
DEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLTGK
DLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEK
EFTDYLFNKSLEIEPRNPKQPPRFPRKSTFSLKSPGIRPN
3D structure
PDB8uh0 Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.
ChainA
Resolution2.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WRN A Y882 D885 F888 D900 Y283 D286 F289 D301
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:8uh0, PDBe:8uh0, PDBj:8uh0
PDBsum8uh0
PubMed38156904
UniProtQ07890|SOS2_HUMAN Son of sevenless homolog 2 (Gene Name=SOS2)

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