Structure of PDB 8ugt Chain A

Receptor sequence
>8ugtA (length=580) Species: 39485 (Lachnospira eligens) [Search protein sequence]
AMLYPVLTQSRLLSDLSGVWNFKLDNGKGFEEKWYEKPLKDADTMPVPAS
YNDLKEGTDFRDHYGWVFYQRNISVPEYVKSQRIVLRCAAVTHYAMIYLN
GKLICEHKGGFLPFEVELNDDLQDGDNLLTIAVNNVIDYTTLPVGGKAPQ
NNPNFDFFNYCGITRPVKIYTTPETYINDITVTADIDFTKEEPSAVLNYN
VEIKGITCKVELFDEEGTKLSETEGSEGTFEISNVRLWQPLNAYLYKIKV
TAGQDVYTLPYGVRSVRVDGTKFLINEKPFYFKGYGKHEDTFPNGRGINL
PMNTKDISIMKWQHANSFRTSHYPYSEEMMRLCDEEGIVVIDETTAVGVN
LQFERIGTFDKEHGVQTQEHHKDVIRDLISRDKNHACVVMWSIANEPDSA
AEGAYDYFKPLYDLARELDPQKRPCTLVSVQGTTADTDCSSQLSDVICLN
RYYGWYFGGPDLEVSETGLRKELSDWGKLGKPVMFTEYGADTVSGLHDTT
SVMYTEEYQVEYYEMNNKVFDEFDFVVGEQAWNFADFATSQSLLRVQGNK
KGLFTRDRKPKMVAHYFRNRWSAIPEFGYK
3D structure
PDB8ugt Advanced piperazine-containing inhibitors target microbial beta-glucuronidases linked to gut toxicity
ChainA
Resolution2.65 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WOF A D172 H343 N424 E425 Y481 Y485 F486 E516 W561 N578 K580 D156 H322 N395 E396 Y452 Y456 F457 E487 W532 N549 K551
Gene Ontology
Molecular Function
GO:0004565 beta-galactosidase activity
GO:0004566 beta-glucuronidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding

View graph for
Molecular Function
External links
PDB RCSB:8ugt, PDBe:8ugt, PDBj:8ugt
PDBsum8ugt
PubMed39211470
UniProtA0A174ZZA3

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